1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Base Information

Chemical Name:1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS No.:122551-50-2
Molecular Formula:C₁₇H₉F₄NO₄
Molecular Weight:367.256
Hs Code.:

Synonyms:1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

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Chemical Property of 1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

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Technology Process of 1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

There total 5 articles about 1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 122551-47-7
1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 122551-50-2
1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: With sulfuric acid; In water; acetic acid; for 1.5h; Heating;
DOI:10.1002/jps.2600780716

Reference yield:

: 22225-77-0
1-difluoromethoxy-2-nitro-benzene

: 122551-50-2
1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / H₂ / Pd/C / ethanol; H₂O / 0.33 h / Ambient temperature

2: 54.3 percent / ethanol / 1 h / Ambient temperature

3: 88 percent / Na₂CO₃ / dimethylformamide / 1) room temperature, 30 min; 2) 100 deg C, 30 min

4: 91 percent / conc. H₂SO₄ / acetic acid; H₂O / 1.5 h / Heating

With sulfuric acid; hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600780716

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 122551-50-2
1-<2-(difluoromethoxy)phenyl>-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / aq. NaOH / tetrahydrofuran / 24 h / Ambient temperature

2: 76 percent / H₂ / Pd/C / ethanol; H₂O / 0.33 h / Ambient temperature

3: 54.3 percent / ethanol / 1 h / Ambient temperature

4: 88 percent / Na₂CO₃ / dimethylformamide / 1) room temperature, 30 min; 2) 100 deg C, 30 min

5: 91 percent / conc. H₂SO₄ / acetic acid; H₂O / 1.5 h / Heating

With sodium hydroxide; sulfuric acid; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600780716