4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine

Base Information

• Chemical Name: 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine
• CAS No.: 1085525-61-6
• Molecular Formula: C₁₆H₁₆F₃N₃O₂S
• Molecular Weight: 371.383

Synonyms:4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine

Chemical Property of 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine

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Technology Process of 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine

There total 1 articles about 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1-(ethoxycarbonyl)-1,2,3,6-tetrahydropyridine (1085525-59-2) → 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine (1085525-61-6)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1016/j.bmc.2008.08.059

Reference yield: 53.0%

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine (1085525-61-6) → 4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1-nitroso-1,2,3,6-tetrahydropyridine (1085525-63-8)

Guidance literature:

With nitrogen(II) oxide; sodium methylate; In methanol; diethyl ether; acetonitrile; at 25 ℃; for 48h; under 2068.65 Torr;

DOI:10.1016/j.bmc.2008.08.059

Reference yield: 47.0%

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridine (1085525-61-6) + 4-(nitrooxy)butyl bromide (146563-40-8) → 1-(4-methanesulfonylphenyl)-5-[1-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl]-3-trifluoromethyl-1H-pyrazole (1219688-99-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

DOI:10.1016/j.bmcl.2010.01.014

upstream raw materials:

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1-(ethoxycarbonyl)-1,2,3,6-tetrahydropyridine

Downstream raw materials:

4-[2-(4-(methanesulfonyl)phenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-1-nitroso-1,2,3,6-tetrahydropyridine

1-(4-methanesulfonylphenyl)-5-[1-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl]-3-trifluoromethyl-1H-pyrazole

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