146563-40-8

Basic information

• Product Name: 4-bromobutyl nitrate
• Synonyms: 4-bromobutyl nitrate
• CAS NO: 146563-40-8
• Molecular Formula: C₄H₈BrNO₃
• Molecular Weight: 198.02
• Mol File: 146563-40-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-bromobutyl nitrate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromobutyl nitrate(146563-40-8)
• EPA Substance Registry System: 4-bromobutyl nitrate(146563-40-8)

Safety Data

• Hazardous Substances Data: 146563-40-8(Hazardous Substances Data)

Usage

Uses

4-bromobutyl nitrate is an intermediate in synthesizing Latanoprostene Bunod (L177335). It is a derivative of Latanoprost and is used in the treatment of interocular pressure.

Preparation

4-Bromobutyl nitrate is a thermally unstable oily liquid, which is used to obtain nitrooxyalkyl esters of pharmacologically active carboxylic acids (WO 04/020384, WO 04/020385). 4-Bromobutyl nitrate not dissolved in solvents is added to the solution / suspension of pharmacologically active carboxylic acids such as naproxen, ferulic acid, etc. 4-Bromobutyl nitrate is obtained by nitration with a sulfonitizing mixture of 4-bromo-1-hydroxybutane (Chem. Pharm. Bull., 1993, 41, p. 1040). The reaction is carried out by adding 4-bromo-1-hydroxybutane to the crude sulphonating mixture in the absence of solvents or diluents. The reaction is limited to a laboratory scale since the method is potentially explosive due to a sudden increase in temperature and gas production.https://patents.google.com/patent/RU2388746C2/en

Upstream product

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