methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

Base Information

Chemical Name:methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate
CAS No.:1431556-33-0
Molecular Formula:C₂₁H₂₃Cl₂NO₄
Molecular Weight:424.324
Hs Code.:

Synonyms:methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

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Chemical Property of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

Chemical Property:

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Technology Process of methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

There total 4 articles about methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1431556-33-0
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 48 h / 70 °C / Inert atmosphere

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/C8MD00320C

Reference yield:

: 406680-76-0
C₁₉H₃₀NO₈P

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 1431556-33-0
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

Guidance literature:: With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; In 1,4-dioxane; at 110 ℃;

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 1431556-33-0
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 48 h / 70 °C / Inert atmosphere

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/C8MD00320C