N-Boc-4-broMo-L-phenylalanine Methyl ester

Base Information

• Chemical Name: N-Boc-4-broMo-L-phenylalanine Methyl ester
• CAS No.: 266306-18-7
• Molecular Formula: C15H20BrNO4
• Molecular Weight: 358.232
• Mol file: 266306-18-7.mol

Synonyms:N-Boc-4-broMo-L-phenylalanine Methyl ester;(S)-2-(Boc-amino)-3-(4-bromophenyl)propionic acid methyl este

Chemical Property of N-Boc-4-broMo-L-phenylalanine Methyl ester

Chemical Property:

• PSA: 68.12000
• LogP: 3.26230
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-Methyl3-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-4-broMo-L-phenylalanine Methyl ester

There total 9 articles about N-Boc-4-broMo-L-phenylalanine Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-3-(4-bromophenyl)propionic acid methyl ester hydrochloride (99359-32-7) → (S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester (266306-18-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 96.0%

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine (62129-39-9,79561-82-3) + methyl iodide (74-88-4) → (S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester (266306-18-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 57.0%

1,4-bromoiodobenzene (589-87-7) + N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → (S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester (266306-18-7)

Guidance literature:

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; for 0.0833333h;

1,4-bromoiodobenzene; With tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Further stages.;

DOI:10.1016/j.tet.2007.11.031

upstream raw materials:

1,4-bromoiodobenzene

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

methyl iodide

Downstream raw materials:

1-{(2S)-2-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)]ethyl}-4-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)ethyl}-benzene

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-vinylphenyl)propionate