(S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester
CAS No.:174833-41-1
Molecular Formula:C₂₄H₃₈N₂O₇Si
Molecular Weight:494.66
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

There total 5 articles about (S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 36239-09-5
ethyl chlorocarbonylacetate

: 174833-40-0
N-α-tert-butyloxycarbonyl-β-(p-aminophenyl)-L-alanine 2-(trimethylsilyl)ethyl ester

: 174833-41-1
(S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With pyridine; In dichloromethane; 1.) 0 deg C, 15 min, 2.) room temperature, 36 h;
DOI:10.1021/jo951855a

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174833-41-1
(S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / 1N NaOH / dioxane; H₂O / 3 h / Ambient temperature

2: 97 percent / pyridine, DCC / acetonitrile / 1 h / 0 °C

3: 84 percent / H₂ / 10percent Pd-C / methanol / 3 h / 2585.7 Torr / Ambient temperature

4: 52 percent / pyridine / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 36 h

With pyridine; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo951855a

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 174833-41-1
(S)-2-tert-Butoxycarbonylamino-3-[4-(2-ethoxycarbonyl-acetylamino)-phenyl]-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / pyridine, DCC / acetonitrile / 1 h / 0 °C

2: 84 percent / H₂ / 10percent Pd-C / methanol / 3 h / 2585.7 Torr / Ambient temperature

3: 52 percent / pyridine / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 36 h

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo951855a