Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester
CAS No.:140367-98-2
Molecular Formula:C₃₂H₅₁NO₆SSi
Molecular Weight:605.912
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

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Chemical Property of Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

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Technology Process of Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

There total 10 articles about Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 140368-01-0
Toluene-4-sulfonic acid (Z)-(S)-6-[(S)-2-(4-methoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-3-triisopropylsilanyloxy-hex-4-enyl ester

: 140367-98-2
Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/0040-4039(91)80195-C

Reference yield:

: 140368-00-9
2-[(S)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-ethanol

: 140367-98-2
Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / bisacodyl / dichloromethane

2: sodium hydrogencarbonate; lithium bromide / N,N-dimethyl-formamide / 70 °C

3: acetonitrile / Heating

4: potassium hexamethylsilazane / -78 °C

5: triethylamine / dmap / dichloromethane

6: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

With potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; lithium bromide; dmap; bisacodyl; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4039(91)80195-C

Reference yield:

: 140367-94-8
[(S)-2-(4-Methoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-acetaldehyde

: 140367-98-2
Toluene-4-sulfonic acid (Z)-(3S,7S)-8-hydroxy-7-(4-methoxy-benzylamino)-3-triisopropylsilanyloxy-oct-4-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / methanol

2: triethylamine / bisacodyl / dichloromethane

3: sodium hydrogencarbonate; lithium bromide / N,N-dimethyl-formamide / 70 °C

4: acetonitrile / Heating

5: potassium hexamethylsilazane / -78 °C

6: triethylamine / dmap / dichloromethane

7: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

With sodium tetrahydroborate; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; lithium bromide; dmap; bisacodyl; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4039(91)80195-C