5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

Base Information

Chemical Name:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide
CAS No.:747413-16-7
Molecular Formula:C₂₆H₂₂ClIN₂O₄
Molecular Weight:588.829
Hs Code.:

Synonyms:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

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Chemical Property of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

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Technology Process of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

There total 1 articles about 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 747413-05-4
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide

: 747413-16-7
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

Guidance literature:: With N-iodo-succinimide; ammonium cerium (IV) nitrate; In acetonitrile; for 1.5h; Reflux;
DOI:10.1021/acs.jmedchem.6b01478

Reference yield: 82.0%

: 747413-16-7
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

: 87199-17-5
4-formylphenylboronic acid,

: 747413-34-9
5-(2,4-bis(benzyloxy)-5-chlorophenyl)-4-(4-formylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 65h;

Reference yield: 81.0%

: 747413-16-7
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide

: 24424-99-5
di-tert-butyl dicarbonate

: 51239-46-4
4-(aminomethyl)phenylboronic acid

: tert-butyl-N-[(4-{5-[2,4-bis(benzyloxy)-5-chlorophenyl]-3-(ethylcarbamoyl)-1,2-oxazol-4-yl}phenyl)methyl]carbamate

Guidance literature:: di-tert-butyl dicarbonate; 4-(aminomethyl)phenylboronic acid; With trimethylamine; In N,N-dimethyl-formamide; for 1h;

5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-ethyl-4-iodo-1,2-oxazole-3-carboxamide; With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01478