N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine

Base Information

• Chemical Name: N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine
• CAS No.: 249286-91-7
• Molecular Formula: C₂₉H₄₄N₄O₇Si
• Molecular Weight: 588.776

Synonyms:N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine

Chemical Property of N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine

There total 3 articles about N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(benzyloxycarbonylamino)hexanoic acid (1947-00-8) + β-D-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine (51549-27-0) → N4-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine (249286-91-7)

Guidance literature:

β-D-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine; With 1,1,1,3,3,3-hexamethyl-disilazane; for 12h;

6-(benzyloxycarbonylamino)hexanoic acid; With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 50 ℃; for 40h;

DOI:10.1016/S0008-6215(99)00074-9

Reference yield:

2'-deoxycytidine monohydrochloride (3992-42-5) → N4-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine (249286-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide / 3 h / 20 °C

2.1: HMDSA / 12 h

2.2: 2-chloro-N-methylpyridinium iodide; N,N-diisopropylethylamine / dioxane / 40 h / 50 °C

With 1H-imidazole; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide; 1.1: Substitution / 2.1: silylation / 2.2: Acylation;

DOI:10.1016/S0008-6215(99)00074-9

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N4-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine (249286-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide / 3 h / 20 °C

2.1: HMDSA / 12 h

2.2: 2-chloro-N-methylpyridinium iodide; N,N-diisopropylethylamine / dioxane / 40 h / 50 °C

With 1H-imidazole; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide; 1.1: Substitution / 2.1: silylation / 2.2: Acylation;

DOI:10.1016/S0008-6215(99)00074-9

upstream raw materials:

6-(benzyloxycarbonylamino)hexanoic acid

β-D-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine

2'-deoxycytidine monohydrochloride

tert-butyldimethylsilyl chloride

Downstream raw materials:

N⁴-(6-benzyloxycarbonylaminohexanoyl)-3'-O-benzoyl-2'-deoxycytidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 249286-91-7 N⁴-(6-benzyloxycarbonylaminohexanoyl)-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send