(4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one

Base Information

• Chemical Name: (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one
• CAS No.: 134458-52-9
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 134458-52-9.mol

Synonyms:(4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one

Chemical Property of (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one

There total 2 articles about (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methyl-5-phenyloxazolidin-2-one (77943-39-6) + 4-methylvaleroyl chloride (38136-29-7) → (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one (134458-52-9)

Guidance literature:

4-methyl-5-phenyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.25h; Inert atmosphere;

4-methylvaleroyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/chem.201604445

Reference yield: 80.0%

4-methyl-5-phenyl-2-oxazolidinone (54418-69-8) + 4-methylvaleroyl chloride (38136-29-7) → (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one (134458-52-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -10 - 0 ℃;

Reference yield: 80.0%

(4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyl-oxazolidin-2-one (134458-52-9) + 1-({[(2E)-4-bromobut-2-en-1-yl]oxy}methyl)-4-methoxybenzene → C28H35NO5

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at -78 - -15 ℃; for 2.16667h;

DOI:10.1002/anie.200702142

upstream raw materials:

4-methyl-5-phenyloxazolidin-2-one

4-methylvaleroyl chloride

4-methyl-5-phenyl-2-oxazolidinone

Downstream raw materials:

3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isobutyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

3-<3(R)-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isobutyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

(S)-5-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidine-3-carbonyl)hexanenitrile

(4R,5S)-3-((2R,3S)-3-Hydroxy-2-isobutyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one