N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Base Information

• Chemical Name: N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
• CAS No.: 339291-87-1
• Molecular Formula: C₂₂H₂₄N₂O₅
• Molecular Weight: 396.443

Synonyms:N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Chemical Property of N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Chemical Property:

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Technology Process of N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

There total 1 articles about N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(11aS)-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione (132622-12-9) + chloromethyl methyl ether (107-30-2) → N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione (339291-87-1)

Guidance literature:

(11aS)-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/jo010043d

Reference yield: 75.0%

N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione (339291-87-1) → N-(2-methylamino-4-benzyloxy-5-methoxybenzoyl)-2-hydroxymethylpyrrolidine

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃;

DOI:10.1016/S0040-4020(98)00795-9

Reference yield: 50.0%

N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione (339291-87-1) → 8-benzyl DC-81 (127810-79-1)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at -10 ℃; for 8h;

DOI:10.1021/jo010043d

upstream raw materials:

(11aS)-8-(benzyloxy)-1,2,3,10,11,11a-hexahydro-7-methoxy-5H-pyrrolo<2,1-c><1,4>benzodiazepine-5,11-dione

chloromethyl methyl ether

Downstream raw materials:

8-benzyl DC-81

(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

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