8-benzyl DC-81

Base Information

• Chemical Name: 8-benzyl DC-81
• CAS No.: 127810-79-1
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 127810-79-1.mol

Synonyms:8-benzyl DC-81

Chemical Property of 8-benzyl DC-81

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-benzyl DC-81

There total 40 articles about 8-benzyl DC-81 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-[2-azido-4-(benzyloxy)-5-methoxybenzoyl]prolinal (166117-58-4) → 8-benzyl DC-81 (127810-79-1)

Guidance literature:

With triphenylphosphine; In toluene; for 2.5h; Ambient temperature;

DOI:10.1021/jo00118a016

Reference yield: 71.0%

(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carbaldehyde (140693-22-7) → 8-benzyl DC-81 (127810-79-1)

Guidance literature:

(S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carbaldehyde; With sodium dithionite; In tetrahydrofuran; water; for 8h;

With hydrogenchloride; In methanol; water; for 1h; pH=2;

Reference yield: 68.0%

(2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal (127810-78-0) → 8-benzyl DC-81 (127810-79-1)

Guidance literature:

With calcium carbonate; mercury dichloride; In water; acetonitrile; for 24h; Ambient temperature;

DOI:10.1055/s-1990-26795

upstream raw materials:

(2S)-N-(2-amino-4-benzyloxy-5-methoxybenzoyl)pyrrolidine-2-carbaldehyde diethyl dithioacetal

1-[2-azido-4-(benzyloxy)-5-methoxybenzoyl]prolinal

(S)-8-Benzyloxy-7,11-dimethoxy-1,2,3,10,11,11a-hexahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

N-(10-methoxymethyl)-8-benzyloxy-7-methoxypyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

Downstream raw materials:

(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one