(8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

Base Information

Chemical Name:(8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol
CAS No.:1323140-46-0
Molecular Formula:C₃₀H₅₂O₄Si
Molecular Weight:504.826
Hs Code.:

Synonyms:(8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

Suppliers and Price of (8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

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Chemical Property of (8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

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Technology Process of (8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

There total 5 articles about (8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 503088-34-4
(tert-butyl){[(1R)-1-butylprop-2-yn-1-yl]oxy}dimethylsilane

: 531513-01-6
9-(4-methoxy-benzyloxy)-nonanal

: 1323140-46-0
(8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

Guidance literature:: (tert-butyl){[(1R)-1-butylprop-2-yn-1-yl]oxy}dimethylsilane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

9-(4-methoxy-benzyloxy)-nonanal; In tetrahydrofuran; hexane; at -78 ℃; for 3h;
DOI:10.1002/hlca.201000371

Reference yield:

: C₇H₁₃ClO

: 1323140-46-0
(8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -40 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: 3 h / -78 °C

With 1H-imidazole; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/hlca.201000371

Reference yield:

: 1002-36-4
hep-2-yn-1-ol

: 1323140-46-0
(8R)-8-{[ (tert-butyl)dimethylsilyl]oxy}-16-[(4-methoxybenzyl)oxy]hexadec-6-yn-8-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Reflux

2.1: titanium(IV) isopropylate; Cumene hydroperoxide; D-(-)-diisopropyl tartrate / dichloromethane / -20 °C

3.1: tetrachloromethane; sodium hydrogencarbonate; triphenylphosphine / 3 h / Reflux

4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -40 °C / Inert atmosphere

5.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

6.2: 3 h / -78 °C

With 1H-imidazole; titanium(IV) isopropylate; tetrachloromethane; lithium aluminium tetrahydride; n-butyllithium; Cumene hydroperoxide; sodium hydrogencarbonate; D-(-)-diisopropyl tartrate; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 2.1: Sharpless epoxidation;
DOI:10.1002/hlca.201000371