methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

Base Information

Chemical Name:methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate
CAS No.:248948-46-1
Molecular Formula:C₂₈H₄₀N₂O₈
Molecular Weight:532.634
Hs Code.:

methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

Synonyms:methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

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Chemical Property of methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

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Technology Process of methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

There total 5 articles about methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 248948-42-7
methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]amino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

: 74-88-4
methyl iodide

: 248948-46-1
methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 2h;
DOI:10.1021/ja991160h

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 248948-46-1
methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / H₂ / 5 percent Pd/C / ethanol / 760 Torr

2: 92 percent / NaH / dimethylformamide / 2 h / 25 °C

With hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Methylation;
DOI:10.1021/ja991160h

Reference yield:

: (S)-2-(11-Hydroxy-10-oxo-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradec-9-yl)-3-(4-methoxy-phenyl)-propionic acid methyl ester

: 248948-46-1
methyl (αS,3S)-11-[[(1,1-dimethylethoxy)carbonyl]methylamino]-α-[(4-methoxyphenyl)methyl]-10-oxo-1,4-dioxa-9-azadispiro[4.2.4.2]tetradecane-9-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP / CH₂Cl₂ / 12 h / 25 °C

2: NaN₃ / dimethylformamide / 12 h / 25 °C

3: 90 percent / H₂ / 5 percent Pd/C / ethanol / 760 Torr

4: 92 percent / NaH / dimethylformamide / 2 h / 25 °C

With dmap; sodium azide; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Tosylation / 2: Substitution / 3: Hydrogenolysis / 4: Methylation;
DOI:10.1021/ja991160h