(5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester
• CAS No.: 239804-62-7
• Molecular Formula: C₁₆H₂₅NO₂S
• Molecular Weight: 295.446
• Mol file: 239804-62-7.mol

Synonyms:(5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester

Chemical Property of (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester

There total 6 articles about (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Boc-protected 3-tert-butyl-6-methyl-4-thiocyanatoaniline (239804-61-6) → (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester (239804-62-7)

Guidance literature:

With diothiothreitol; In ethanol; for 16h; Heating;

DOI:10.1021/ol0056170

Reference yield:

4-tert-butyltoluene (98-51-1) → (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester (239804-62-7)

Guidance literature:

Multi-step reaction with 5 steps

1: HNO₃, H₂SO₄

2: H₂ / 20 percent Pd/C

3: 75 percent / NaBr, Br₂

4: aq. NaOH

5: DTT, KH₂PO₄ buffer / ethanol

With sodium hydroxide; KH₂PO₄ buffer; DL-dithiothreitol; sulfuric acid; hydrogen; bromine; nitric acid; sodium bromide; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(99)00237-1

Reference yield:

4-tert-butyl-2-nitrotoluene (62559-08-4) → (5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester (239804-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 20 percent Pd/C

2: 75 percent / NaBr, Br₂

3: aq. NaOH

4: DTT, KH₂PO₄ buffer / ethanol

With sodium hydroxide; KH₂PO₄ buffer; DL-dithiothreitol; hydrogen; bromine; sodium bromide; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(99)00237-1

upstream raw materials:

Boc-protected 3-tert-butyl-6-methyl-4-thiocyanatoaniline

4-tert-butyltoluene

4-tert-butyl-2-nitrotoluene

5-tert-butyl-2-methylaniline

Downstream raw materials:

Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester