Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester

Base Information

• Chemical Name: Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester
• CAS No.: 239804-63-8
• Molecular Formula: C₂₃H₃₁NO₄S₂
• Molecular Weight: 449.635
• Mol file: 239804-63-8.mol

Synonyms:Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester

Chemical Property of Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester

There total 6 articles about Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butyltoluene (98-51-1) → Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester (239804-63-8)

Guidance literature:

Multi-step reaction with 6 steps

1: HNO₃, H₂SO₄

2: H₂ / 20 percent Pd/C

3: 75 percent / NaBr, Br₂

4: aq. NaOH

5: DTT, KH₂PO₄ buffer / ethanol

6: Et₃N

With sodium hydroxide; KH₂PO₄ buffer; DL-dithiothreitol; sulfuric acid; hydrogen; bromine; nitric acid; triethylamine; sodium bromide; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(99)00237-1

Reference yield:

4-tert-butyl-2-nitrotoluene (62559-08-4) → Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester (239804-63-8)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 20 percent Pd/C

2: 75 percent / NaBr, Br₂

3: aq. NaOH

4: DTT, KH₂PO₄ buffer / ethanol

5: Et₃N

With sodium hydroxide; KH₂PO₄ buffer; DL-dithiothreitol; hydrogen; bromine; triethylamine; sodium bromide; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(99)00237-1

Reference yield:

5-tert-butyl-2-methylaniline (85336-17-0) → Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester (239804-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / NaBr, Br₂

2: aq. NaOH

3: DTT, KH₂PO₄ buffer / ethanol

4: Et₃N

With sodium hydroxide; KH₂PO₄ buffer; DL-dithiothreitol; bromine; triethylamine; sodium bromide; In ethanol;

DOI:10.1016/S0960-894X(99)00237-1

upstream raw materials:

toluene-p-sulfonyl bromide

(5-tert-Butyl-4-mercapto-2-methyl-phenyl)-carbamic acid tert-butyl ester

4-tert-butyltoluene

4-tert-butyl-2-nitrotoluene

Downstream raw materials:

toluene-4-thiosulfonic acid S-(4-amino-2-tert-butyl-5-methylphenyl) ester