3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

Base Information

Chemical Name:3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one
CAS No.:1221486-12-9
Molecular Formula:C₂₁H₁₃F₂N₅O₂
Molecular Weight:405.363
Hs Code.:

Synonyms:3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

Suppliers and Price of 3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

There total 9 articles about 3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221486-06-1
3-(2,4-difluorophenylamino)-8-amino-6H-dibenzo[b,e]oxepin-11-one

: 149-73-5
trimethyl orthoformate

: 1221486-12-9
3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

Guidance literature:: With sodium azide; acetic acid; at 100 ℃;

Reference yield:

: 133446-99-8
2-bromomethyl-4-nitro-benzoic acid methyl ester

: 1221486-12-9
3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 0.25 h / 20 °C

1.2: 6 h / 70 °C

2.1: potassium hydroxide; water / methanol / 40 °C / Reflux

3.1: polyphosphoric acid / sulfolane / 2 h / 100 °C / Inert atmosphere

3.2: 20 °C / Cooling with ice

4.1: hydrogenchloride / methanol / 4 h / Reflux

5.1: potassium tert-butylate; XPhos / palladium diacetate / toluene; tert-butyl alcohol / 2 h / 110 °C / Inert atmosphere

5.2: Cooling with ice

6.1: tin(II) chloride dihdyrate / ethanol / 2 h / 100 °C

7.1: sodium azide; acetic acid / 100 °C

With hydrogenchloride; sodium azide; tin(II) chloride dihdyrate; potassium tert-butylate; water; potassium carbonate; acetic acid; potassium hydroxide; XPhos; palladium diacetate; In sulfolane; methanol; ethanol; acetone; toluene; tert-butyl alcohol;

Reference yield:

: 1221486-71-0
3-Acetamido-8-nitro-6H-dibenzo[b,e]oxepin-11-one

: 1221486-12-9
3-(2,4-Difluorophenylamino)-8-tetrazol-1-yl-6H-dibenzo[b,e]oxepin-11-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 4 h / Reflux

2.1: potassium tert-butylate; XPhos / palladium diacetate / toluene; tert-butyl alcohol / 2 h / 110 °C / Inert atmosphere

2.2: Cooling with ice

3.1: tin(II) chloride dihdyrate / ethanol / 2 h / 100 °C

4.1: sodium azide; acetic acid / 100 °C

With hydrogenchloride; sodium azide; tin(II) chloride dihdyrate; potassium tert-butylate; acetic acid; XPhos; palladium diacetate; In methanol; ethanol; toluene; tert-butyl alcohol;