Technology Process of 5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-1-methyl-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
There total 7 articles about 5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-1-methyl-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate; sodium iodide;
In
N,N-dimethyl acetamide;
at 80 ℃;
for 13h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 48 h / 20 - 40 °C
2: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 24 h / Reflux; Inert atmosphere
3: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; methanol / 48 h / 20 °C
4: sodium hydride / mineral oil; methanol / 1.5 h / Cooling with ice
5: sodium iodide; chloro-trimethyl-silane / acetonitrile / 3.5 h / 20 °C / Reflux
6: sodium iodide; caesium carbonate / N,N-dimethyl acetamide / 13 h / 80 °C
With
chloro-trimethyl-silane; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; sodium iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 21 h / -78 - 20 °C / Inert atmosphere
1.2: pH 5
2.1: toluene / 48 h / 20 - 40 °C
3.1: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 24 h / Reflux; Inert atmosphere
4.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; methanol / 48 h / 20 °C
5.1: sodium hydride / mineral oil; methanol / 1.5 h / Cooling with ice
6.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 3.5 h / 20 °C / Reflux
7.1: sodium iodide; caesium carbonate / N,N-dimethyl acetamide / 13 h / 80 °C
With
n-butyllithium; chloro-trimethyl-silane; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; sodium iodide;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl acetamide; water; toluene; acetonitrile; mineral oil;