Technology Process of 5-hydroxy-1-methyl-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
There total 6 articles about 5-hydroxy-1-methyl-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane; sodium iodide;
In
acetonitrile;
at 20 ℃;
for 3.5h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 21 h / -78 - 20 °C / Inert atmosphere
1.2: pH 5
2.1: toluene / 48 h / 20 - 40 °C
3.1: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 24 h / Reflux; Inert atmosphere
4.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; methanol / 48 h / 20 °C
5.1: sodium hydride / mineral oil; methanol / 1.5 h / Cooling with ice
6.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 3.5 h / 20 °C / Reflux
With
n-butyllithium; chloro-trimethyl-silane; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; potassium carbonate; sodium iodide;
In
tetrahydrofuran; methanol; hexane; water; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene / 48 h / 20 - 40 °C
2: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / toluene; water / 24 h / Reflux; Inert atmosphere
3: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; methanol / 48 h / 20 °C
4: sodium hydride / mineral oil; methanol / 1.5 h / Cooling with ice
5: sodium iodide; chloro-trimethyl-silane / acetonitrile / 3.5 h / 20 °C / Reflux
With
chloro-trimethyl-silane; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; potassium carbonate; sodium iodide;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile; mineral oil;