2-chloro-3-cyano-4-anilinopyridine

Base Information

• Chemical Name: 2-chloro-3-cyano-4-anilinopyridine
• CAS No.: 103607-75-6
• Molecular Formula: C₁₂H₈ClN₃
• Molecular Weight: 229.669
• Mol file: 103607-75-6.mol

Synonyms:2-chloro-3-cyano-4-anilinopyridine

Chemical Property of 2-chloro-3-cyano-4-anilinopyridine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-3-cyano-4-anilinopyridine

There total 5 articles about 2-chloro-3-cyano-4-anilinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-cyano-4-phenylamino-1,2-dihydropyridin-2-one (103607-70-1) → 2-chloro-3-cyano-4-anilinopyridine (103607-75-6)

Guidance literature:

With 2,3-Dimethylaniline; trichlorophosphate; for 2h; Heating;

DOI:10.1007/BF00767827

Reference yield:

α-cyano-β-dimethylaminocrotonamide (62321-92-0) → 2-chloro-3-cyano-4-anilinopyridine (103607-75-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / acetic acid / 4 h / Heating

2: 56 percent / ethanol / 2 h / Heating

3: 69 percent / 1 N NaOH / 1 h / Heating

4: 98 percent / POCl₃, dimethylaniline / 2 h / Heating

With sodium hydroxide; 2,3-Dimethylaniline; trichlorophosphate; In ethanol; acetic acid;

DOI:10.1007/BF00767827

Reference yield:

α-Cyano-β-N-phenylaminocrotonamide (91255-14-0) → 2-chloro-3-cyano-4-anilinopyridine (103607-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / ethanol / 2 h / Heating

2: 69 percent / 1 N NaOH / 1 h / Heating

3: 98 percent / POCl₃, dimethylaniline / 2 h / Heating

With sodium hydroxide; 2,3-Dimethylaniline; trichlorophosphate; In ethanol;

DOI:10.1007/BF00767827

upstream raw materials:

3-cyano-4-phenylamino-1,2-dihydropyridin-2-one

α-cyano-β-dimethylaminocrotonamide

α-Cyano-β-N-phenylaminocrotonamide

1-Phenyl-4-oxo-5-cyano-6-(β-dimethylaminovinyl)-1,4-dihydropyrimidine

Downstream raw materials:

2-(3-Isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-4-phenylamino-nicotinonitrile

methyl 3-[1-(dimethylamino)ethylidene]amino-4-anilinothieno[2,3-b]pyridine-2-carboxylate

ethyl 3-[1-(dimethylamino)ethylidene]amino-4-anilinothieno[2,3-b]pyridine-2-carboxylate

methyl 3-amino-4-anilinothieno[2,3-b]pyridine-2-carboxylate

Refernces