5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid

Base Information

• Chemical Name: 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid
• CAS No.: 18502-39-1
• Molecular Formula: C₁₁H₉N₃O₄
• Molecular Weight: 247.21
• Mol file: 18502-39-1.mol

Synonyms:5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid

Chemical Property of 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid

There total 3 articles about 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.02%

4-azidobenzoic acid (6427-66-3) + ethyl acetoacetate (141-97-9) → 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid (18502-39-1)

Guidance literature:

With sodium; In ethanol; at 0 ℃; for 0.5h;

DOI:10.1039/c6nj01503d

Reference yield: 69.0%

methyl 4-azidobenzoate (20442-96-0) + ethyl acetoacetate (141-97-9) → 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid (18502-39-1)

Guidance literature:

methyl 4-azidobenzoate; ethyl acetoacetate; With sodium ethanolate; In ethanol; for 2h; Reflux;

With sodium hydroxide; In water; for 5h; Reflux;

DOI:10.1016/j.poly.2021.115115

Reference yield:

→ 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid (18502-39-1)

Guidance literature:

5-Methyl-1-(p-methoxycarbonyl-phenyl)-1,2,3-triazol-4-carbonsaeure-ethylester;

DOI:10.1016/S0040-4039(01)89676-3

upstream raw materials:

4-azidobenzoic acid

ethyl acetoacetate

methyl 4-azidobenzoate