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6427-66-3

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6427-66-3 Usage

Uses

Different sources of media describe the Uses of 6427-66-3 differently. You can refer to the following data:
1. 4-AZIDOBENZOIC ACID is a benzoic acid derivative used in photolysis reactions and biomaterial studies.
2. 4-Azidobenzoic acid is an aromatic azide used in copper(I)-catalyzed azide-alkyne cycloaddition reactions.

General Description

4-Azidobenzoic acid is an aromatic azide generally used in copper(I)-catalyzed azide-alkyne cycloaddition reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 6427-66-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,2 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6427-66:
(6*6)+(5*4)+(4*2)+(3*7)+(2*6)+(1*6)=103
103 % 10 = 3
So 6427-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H5N3O2/c8-10-9-6-3-1-5(2-4-6)7(11)12/h1-4,8H/p+1

6427-66-3 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (A0930)  4-Azidobenzoic Acid  >97.0%(HPLC)(T)

  • 6427-66-3

  • 5g

  • 255.00CNY

  • Detail
  • TCI America

  • (A0930)  4-Azidobenzoic Acid  >97.0%(HPLC)(T)

  • 6427-66-3

  • 25g

  • 1,920.00CNY

  • Detail
  • Aldrich

  • (778877)  4-Azidobenzoic acid solution  ~0.2 M in tert-butyl methyl ether, ≥95.0% (HPLC)

  • 6427-66-3

  • 778877-10ML

  • 842.40CNY

  • Detail
  • Aldrich

  • (778877)  4-Azidobenzoic acid solution  ~0.2 M in tert-butyl methyl ether, ≥95.0% (HPLC)

  • 6427-66-3

  • 778877-50ML

  • 3,111.03CNY

  • Detail

6427-66-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Azidobenzoic Acid

1.2 Other means of identification

Product number -
Other names 4-AZIDOBENZOIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6427-66-3 SDS

6427-66-3Relevant articles and documents

Design, synthesis and biological evaluation of novel 4-substituted coumarin derivatives as antitumor agents

An, Ran,Hou, Zhuang,Li, Jian-Teng,Yu, Hao-Nan,Mou, Yan-Hua,Guo, Chun

, (2018)

Herein, fifteen new compounds containing coumarin, 1,2,3-triazole and benzoyl-substituted arylamine moieties were designed, synthesized and tested in vitro for their anticancer activity. The results showed that all tested compounds had moderate antiproliferative activity against MDA-MB-231, a human breast cancer cell line, under both normoxic and hypoxic conditions. Furthermore, the 4-substituted coumarin linked with benzoyl 3,4-dimethoxyaniline through 1,2,3-triazole (compound 5e) displayed the most prominent antiproliferative activities with an IC50 value of 0.03 μM, about 5000 times stronger than 4-hydroxycoumarin (IC50 > 100 μM) and 20 times stronger than doxorubicin (IC50 = 0.60 μM). Meanwhile, almost all compounds revealed general enhancement of proliferation-inhibiting activity under hypoxia, contrasted with normoxia. A docking analysis showed that compound 5e had potential to inhibit carbonic anhydrase IX (CA IX).

Isolation of molybdenum(vi) from simulated leachates of irradiated uranium-aluminum targets using diluted and undiluted sulfate ionic liquids

Raiguel, Stijn,Dehaen, Wim,Binnemans, Koen

, p. 3948 - 3960 (2019)

A method is presented to separate molybdenum from other elements commonly present in oxidative alkaline leachates of irradiated uranium-aluminum targets for the production of molybdenum-99. The separation was accomplished by selective extraction of molybdate anions using triazolium and phosphonium sulfate ionic liquid extractants, either diluted in 1-octanol or undiluted. Molybdenum was then stripped from the organic phase using a sodium hydrogen carbonate solution. The extractant was regenerated by contacting the organic phase with an alkaline sulfate solution. The extraction mechanism and the influence of the diluent on the extractant performance were investigated. The reported method provides a promising alternative to state-of-the-art chromatographic processes, showing potential for limiting the production of radioactive waste.

Nickel Boride Catalyzed Reductions of Nitro Compounds and Azides: Nanocellulose-Supported Catalysts in Tandem Reactions

Proietti, Giampiero,Prathap, Kaniraj Jeya,Ye, Xinchen,Olsson, Richard T.,Dinér, Peter

supporting information, p. 133 - 146 (2021/11/04)

Nickel boride catalyst prepared in situ from NiCl2 and sodium borohydride allowed, in the presence of an aqueous solution of TEMPO-oxidized nanocellulose (0.01 wt%), the reduction of a wide range of nitroarenes and aliphatic nitro compounds. Here we describe how the modified nanocellulose has a stabilizing effect on the catalyst that enables low loading of the nickel salt pre-catalyst. Ni-B prepared in situ from a methanolic solution was also used to develop a greener and facile reduction of organic azides, offering a substantially lowered catalyst loading with respect to reported methods in the literature. Both aromatic and aliphatic azides were reduced, and the protocol is compatible with a one-pot Boc-protection of the obtained amine yielding the corresponding carbamates. Finally, bacterial crystalline nanocellulose was chosen as a support for the Ni-B catalyst to allow an easy recovery step of the catalyst and its recyclability for new reduction cycles.

Antiviral activity of 1,4-disubstituted-1,2,3-triazoles against HSV-1 in vitro

Viegas, Daiane J.,da Silva, Ver?nica D.,Buarque, Camilla D.,Bloom, David C.,Abreu, Paula A.

, p. 399 - 410 (2021/05/31)

Background: Herpes simplex virus 1 (HSV-1) affects a large part of the adult population. Anti-HSV-1 drugs, such as acyclovir, target thymidine kinase and viral DNA polymerase. However, the emerging of resistance of HSV-1 alerts for the urgency in developing new antivirals with other therapeutic targets. Thus, this study evaluated a series of 1,4-disubstituted-1,2,3-triazole derivatives against HSV-1 acute infection and provided deeper insights into the possible mechanisms of action. Methods: Human fibroblast cells (HFL-1) were infected with HSV-1 17syn+ and treated with the triazole compounds at 50 mM for 24 h. The 50% effective drug concentration (EC50) was determined for the active compounds. Their cytotoxicity was also evaluated in HFL-1 with the 50% cytotoxic concentration (CC50) determined using CellTiter-Glo solution. The most promising compounds were evaluated by virucidal activity and influence on virus egress, DNA replication and transcription, and effect on an acyclovir-resistant HSV-1 strain. Results: Compounds 3 ((E)-4-methyl-N'-(2-(4(phenoxymethyl)-1H-1,2,3-triazol1yl)benzylidene)benzenesulfonohydrazide) and 4 (2,2'-(4,4'-((1,3-phenylen ebis(oxy))bis(methylene))bis(1H-1,2,3-triazole-4,1 diyl)) dibenzaldehyde) were the most promising, with an EC50 of 16 and 21 mM and CC50 of 285 and 2,593 mM, respectively. Compound 3 was able to inhibit acyclovir-resistant strain replication and to interfere with virus egress. Both compounds did not affect viral DNA replication, but inhibited significantly the expression of ICP0, ICP4 and gC. Compound 4 also affected the transcription of UL30 and ICP34.5. Conclusions: Our findings demonstrated that these compounds are promising antiviral candidates with different mechanisms of action from acyclovir and further studies are merited.

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