4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide

Base Information

• Chemical Name: 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide
• CAS No.: 1377411-14-7
• Molecular Formula: C₂₁H₃₃N₃O₂
• Molecular Weight: 359.512
• Mol file: 1377411-14-7.mol

Synonyms:4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide

Chemical Property of 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide

There total 3 articles about 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(N-cyclohexanemethylcarbamoyl)benzotriazole (1377411-11-4) + ibuprofen hydrazide (127222-69-9) → 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide (1377411-14-7)

Guidance literature:

With triethylamine; at 75 ℃; for 0.25h;

DOI:10.1016/j.ejmech.2012.02.046

Reference yield:

1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-(4-isobutylphenyl)propan-1-one (230644-97-0) → 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide (1377411-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / 1,4-dioxane / 20 °C

2: triethylamine / 0.25 h / 75 °C

With hydrazine hydrate; triethylamine; In 1,4-dioxane;

DOI:10.1016/j.ejmech.2012.02.046

Reference yield:

cyclohexylmethylamine (3218-02-8) → 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide (1377411-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine

2: triethylamine / 0.25 h / 75 °C

With triethylamine;

DOI:10.1016/j.ejmech.2012.02.046

upstream raw materials:

1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-(4-isobutylphenyl)propan-1-one

1-(N-cyclohexanemethylcarbamoyl)benzotriazole

ibuprofen hydrazide

cyclohexylmethylamine