230644-97-0

Upstream product

• 15687-27-1 ibuprofen 
• 65095-13-8 1-benzotriazolecarboxylic acid chloride 
• 37073-15-7 1-(methanesulfonyl)-1H-1,2,3-benzotriazole 
• 95-14-7 1,2,3-Benzotriazole 

Downstream Products

• 1246302-57-7 3-(4-isobutylphenyl)-1-nitrobutan-2-one 
• 1246302-53-3 N-methoxy-N-methyl-2-(4-isobutylphenyl)propanamide 
• 1377411-13-6 4-cyclohexyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide 
• 1377411-14-7 4-cyclohexanemethyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide 
• 1377411-15-8 4-benzyl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide 
• 1377411-16-9 1-[2-(4-isobutylphenyl)propanoyl]-4-(2-phenylethyl)semicarbazide 
• 1377411-17-0 4-benzhydryl-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide 
• 1377411-30-7 4-benzyloxy-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide 
• 1377411-33-0 4-hydroxy-1-[2-(4-isobutylphenyl)propanoyl]semicarbazide 
• 1377411-37-4 5-benzyloxycarbamoyl-1-[2-(4-isobutylphenyl)propanoyl]carbazide 
• 1377411-40-9 5-hydroxycarbamoyl-1-[2-(4-isobutylphenyl)propanoyl]carbazide 
• 127222-69-9 ibuprofen hydrazide 
• 1567789-61-0 {3-[2-(4-isobutylphenyl)propanamido]propanoyl}-L-histidine 
• 1567789-71-2 [2-(4-isobutylphenyl)propanoyl]-L-histidine 

Relevant academic research and scientific papers

Synthesis of Ibuprofen Hybrid Conjugates as Anti-Inflammatory and Analgesic Agents

Disclosed herein as ibuprofen hybrid conjugates and methods of their use to reduce inflammation, pain, and fever. The ibuprofen conjugates have potent anti-inflammatory and analgesic properties with low potential for ulcerogenic activity. An exemplary com

NSAID conjugates with carnosine and amino acids

Benzotriazole-mediated syntheses of novel bioconjugates of nonsteroidal anti-inflammatory drugs with carnosine and with amino acids were prepared in yields of 50-97% as potential drug candidates. Georg Thieme Verlag Stuttgart . New York.

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/ hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants

The novel 1-acyl-4-cycloalkyl/arylsemicarbazides (5a-y) and 1-acyl-5-benzyloxy/hydroxycarbamoylcarbazides (8a-f) derived from the nonsteroidal anti-inflammatory drugs ibuprofen, fenoprofen and reduced ketoprofen were prepared, fully chemically characteriz

Chemistry around imidazopyrazine and ibuprofen: Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors

Based on the imidazo-[1,2-a]-pyrazin-3-(7H)-one scaffold, a dual action prodrug has been designed for combining antioxidant and anti-inflammatory activities, possibly unmasked upon oxidation. The construction of the target-molecule requires two building blocks, namely a 2-amino-1,4-pyrazine and a 2-ketoaldehyde. Attempts to synthesize the 2-ketoaldehyde (5a) derived from ibuprofen failed, but led to the corresponding 2-ketoaldoxime (7a) which could not be condensed with the pyrazine synthons. However, a model compound, i.e. phenylglyoxal aldoxime, reacted well under microwave activation to furnish novel imidazo[1,2-a]-pyrazine-3-(7H)-imine derivatives (18a,b). These heterobicycles behave as antioxidants by inhibiting the lipid peroxidation, and one compound (18b) is endowed with a significant anti-inflammatory effect in a cellular test. Unexpectedly, all the synthetic intermediates derived from ibuprofen are good inhibitors of FAAH, the most active compound (4a) featuring the 1,3-dithian-2-yl motif.

The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: Synthesis, cytostatic and antiviral activity evaluations

The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cyt

ENHANCED TISSUE PENETRATION PRODRUGS

The present invention relates to derivatives of carboxy-containing drugs for enhancing tissue penetration and pharmaceutical compositions comprising such derivatives.