(7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

Base Information

Chemical Name:(7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether
CAS No.:85236-03-9
Molecular Formula:C₃₀H₅₀OSi
Molecular Weight:454.812
Hs Code.:

Synonyms:(7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

Chemical Property:

Purity/Quality:

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Technology Process of (7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

There total 6 articles about (7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85236-17-5
1-bromo-2-(2-(tert-butyldimethylsilyloxy)ethyl)cycloheptene

: 74723-00-5
(E)-2-Ethynyl-2-methyl-4-(2,6,6-trimethyl-cyclohex-1-enyl)-but-3-enoic acid phenyl ester

: 13994-57-5
3-methoxy-3-methylbut-1-yne

: 21336-32-3
1-(2-hydroxyethyl)cyclohept-1-ene

: 85236-03-9
(7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

: 84303-95-7
2,2,5-trimethyl-5-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-3,4,6(E)-heptatriene

: 2-[2-(tert-Butyl-dimethyl-silanyl)-cyclohept-1-enyl]-ethanol

Guidance literature:: With copper(l) iodide; n-butyllithium; tert.-butyl lithium; Multistep reaction; 1) pentan, -78 deg C, 4.5 h; 2) hexane, -10 deg C, 15 min; 3) -10 deg C, 20 min; 4) -78 deg C, 1 h; 5) ether, 6 h, -78 deg C, room temperature (0.5 h);
DOI:10.1021/ja00349a039

Reference yield:

: 73395-75-2
(E)-2-(but-1-en-3-ynyl)-1,3,3-trimethylcyclohex-1-ene

: 85236-03-9
(7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) hexane, ether, -78 deg C, 0.5 h, 2.) hexane, ether, from -78 to -45 deg C, 3 h

2: pyridine, 4-(dimethylamino)pyridine / 3 h

3: 1.) LiBr, CuI / 1.) ether, THF, 0 deg C, 15 min, 2.) ether, THF, 0 deg C, 1 h

With pyridine; dmap; copper(l) iodide; n-butyllithium; lithium bromide;
DOI:10.1021/jo00213a042

Reference yield:

: 85236-17-5
1-bromo-2-(2-(tert-butyldimethylsilyloxy)ethyl)cycloheptene

: 85236-03-9
(7E)-12,20-tetramethylene-10,14-retro-retinyl tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) tert-BuLi / 1.) pentane, THF, 3 h, 2.) pentane, THF, -78 deg C, 2 h

2: 1.) n-BuLi / 1.) hexane, ether, -78 deg C, 0.5 h, 2.) hexane, ether, from -78 to -45 deg C, 3 h

3: pyridine, 4-(dimethylamino)pyridine / 3 h

4: 1.) LiBr, CuI / 1.) ether, THF, 0 deg C, 15 min, 2.) ether, THF, 0 deg C, 1 h

With pyridine; dmap; copper(l) iodide; n-butyllithium; tert.-butyl lithium; lithium bromide;
DOI:10.1021/jo00213a042