13994-57-5

Basic information

• Product Name: 3-METHOXY-3-METHYL-1-BUTYNE
• Synonyms: 3-METHOXY-3-METHYL-1-BUTYNE;3-METHOXY-3-METHYL-BUT-1-YNE
• CAS NO: 13994-57-5
• Molecular Formula: C₆H₁₀O
• Molecular Weight: 98.14
• Mol File: 13994-57-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: -51-2 °C
• Boiling Point: 81-82 °C
• Appearance: /
• Density: 0.8140 g/cm3
• CAS DataBase Reference: 3-METHOXY-3-METHYL-1-BUTYNE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-3-METHYL-1-BUTYNE(13994-57-5)
• EPA Substance Registry System: 3-METHOXY-3-METHYL-1-BUTYNE(13994-57-5)

Safety Data

• Hazardous Substances Data: 13994-57-5(Hazardous Substances Data)

Usage

General Description

3-Methoxy-3-methyl-1-butyne, also known as MMB, is a chemical compound with the molecular formula C6H12O. It is a clear, colorless liquid with a sharp, fruity odor that is used in the production of pharmaceuticals and perfumes. MMB is classified as a highly flammable liquid and can cause irritation to the skin, eyes, and respiratory system upon contact. It is important to handle and store this chemical with care and follow proper safety precautions to prevent any potential hazards.

Upstream product

• 67-56-1 methanol 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 26452-30-2 1-(3-Methoxy-3-methyl-but-1-ynyl)-cyclohexanol 
• 32904-90-8 4-methyl-4-methoxy-1-phenylpent-2-yne-1-one 
• 132609-13-3 4-Methoxy-4-methyl-1-p-tolyl-pent-2-yn-1-one 
• 933-52-8 2,2,4,4-tetramethyl-1,3-cyclobutanedione 
• 84022-47-9 2,6-dimethyl-6-methoxy-4-heptyn-3-one 
• 131293-10-2 4-Methoxy-4-methyl-1-(4-nitro-phenyl)-pent-1-yn-3-one 
• 131293-15-7 (Z)-3-Diethylamino-4-methoxy-4-methyl-1-(4-nitro-phenyl)-pent-2-en-1-one 
• 34943-46-9 (C₆H₅)2SbCCC(OCH₃)(CH₃)2 

Relevant articles and documents

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design

A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding site of the closely related Glucagon receptor (GCGR) (Jazayeri et al., 2016) and the homology relationships between GCGR and GLP-1R. The region around residue C3476.36b of the GLP-1R receptor represents a key difference from GCGR and was targeted for selectivity for GLP-1R.

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Palladium-Catalyzed [2+1] Cycloadditions Affording Vinylidenecyclopropanes as Precursors of 7-Membered Carbocycles

Palladium(II) acetate in association with secondary phosphine oxides provides an efficient catalytic system for [2+1] cycloadditions starting from oxanorbornene derivatives and tertiary propargyl esters giving rise to vinylidenecyclopropanes. This reaction is specific to bidentate phosphinito-phosphinous acid ligands generated from secondary phosphine oxides. The [2+1] cycloaddition was found broad in scope with a high tolerance to various functional groups. Moreover, vinylidenecyclopropanes were straightforwardly converted into oxabicyclo[3.2.1]oct-2-ene derivatives through a palladium-catalyzed ring-expansion. Finally, the oxa bridge cleavage of oxatricyclic compounds yields functionalized 7-membered carbocycles.