3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Base Information

Chemical Name:3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
CAS No.:1376334-38-1
Molecular Formula:C₂₃H₂₃F₅N₄O
Molecular Weight:466.454
Hs Code.:

Synonyms:3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

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Chemical Property of 3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

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Technology Process of 3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

There total 12 articles about 3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.2%

: 1254981-30-0
7-chloro-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

: 1254981-53-7
4-(3,6-difluoro-2-methoxy-phenyl)-piperidine

: 1376334-38-1
3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 190 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1208076-11-2
2-bromo-1,4-difluoro-3-methoxy-benzene

: 1376334-38-1
3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 150 °C / Microwave irradiation

2: hydrogen / palladium(II) hydroxide / ethanol / 80 °C

3: hydrogenchloride / isopropyl alcohol; methanol / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / 0.33 h / 190 °C / Microwave irradiation

With hydrogenchloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol;

Reference yield:

: 2713-31-7
2,5-difluorophenol

: 1376334-38-1
3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; isopropylamine / tetrahydrofuran / -40 - 20 °C

2: potassium carbonate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 150 °C / Microwave irradiation

4: hydrogen / palladium(II) hydroxide / ethanol / 80 °C

5: hydrogenchloride / isopropyl alcohol; methanol / 1.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / 0.33 h / 190 °C / Microwave irradiation

With hydrogenchloride; N-Bromosuccinimide; hydrogen; potassium carbonate; isopropylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol; acetonitrile;