tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Base Information

Chemical Name:tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate
CAS No.:1431546-81-4
Molecular Formula:C₃₀H₃₈N₂O₆
Molecular Weight:522.642
Hs Code.:

Synonyms:tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

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Chemical Property of tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

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Technology Process of tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

There total 6 articles about tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1290056-80-2
tert-butyl N-[[3-[1-[3-[2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

: 1431546-81-4
tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Guidance literature:: tert-butyl N-[[3-[1-[3-[2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 27741-65-7
α-(ethoxycarbonyl)methylenecyclobutane

: 1431546-81-4
tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -20 °C

2.2: 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

5.1: osmium(VIII) oxide / acetone; water / 0.17 h / 20 °C

5.2: 20 °C

6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C

With osmium(VIII) oxide; oxalyl dichloride; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; diisobutylaluminium hydride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; acetone; toluene;

Reference yield:

: 1290056-79-9
tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

: 1431546-81-4
tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide / acetone; water / 0.17 h / 20 °C

1.2: 20 °C

2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

With osmium(VIII) oxide; oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; water; acetone;