tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Base Information

Chemical Name:tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate
CAS No.:1290056-79-9
Molecular Formula:C₃₀H₃₈N₂O₄
Molecular Weight:490.643
Hs Code.:

Synonyms:tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

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Chemical Property of tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

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Technology Process of tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

There total 12 articles about tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1290056-78-8
3-(2-cyclobutylideneethoxy)benzoic acid

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 1290056-79-9
tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1290056-79-9
tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

4.1: hydrogen / palladium-on-charcoal / methanol / 1 h

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

With sodium tetrahydroborate; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;

Reference yield:

: 27741-65-7
α-(ethoxycarbonyl)methylenecyclobutane

: 1290056-79-9
tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -20 °C

2.2: 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;