N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide

Base Information

• Chemical Name: N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide
• CAS No.: 1584679-87-7
• Molecular Formula: C₂₅H₃₄N₄O₃S
• Molecular Weight: 470.636
• Mol file: 1584679-87-7.mol

Synonyms:N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide

Chemical Property of N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide

There total 3 articles about N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3,4-dimethoxybenzylidenemalononitrile (2972-80-7) + N-[5-(cyanomethyl)-1,3,4-thiadiazol-2-yl]dodecanamide (1584679-81-1) → N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide (1584679-87-7)

Guidance literature:

With piperidine; In ethanol; for 4h; Reflux;

DOI:10.1080/00397911.2013.846381

Reference yield:

n-dodecanoyl chloride (112-16-3) → N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide (1584679-87-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 0.5 h / Reflux

2: 2 h / Reflux

3: piperidine / ethanol / 4 h / Reflux

With piperidine; In 1,4-dioxane; ethanol; 3: |Michael Addition;

DOI:10.1080/00397911.2013.846381

Reference yield:

1-(2-cyanoacetyl)-4-dodecanoyl thiosemicarbazide (1584679-80-0) → N-(5-(1-cyano-2-(3,4-dimethoxyphenyl)vinyl)-1,3,4-thiadiazol-2-yl)dodecanamide (1584679-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 h / Reflux

2: piperidine / ethanol / 4 h / Reflux

With piperidine; In ethanol; 2: |Michael Addition;

DOI:10.1080/00397911.2013.846381

upstream raw materials:

n-dodecanoyl chloride

3,4-dimethoxybenzylidenemalononitrile

N-[5-(cyanomethyl)-1,3,4-thiadiazol-2-yl]dodecanamide

1-(2-cyanoacetyl)-4-dodecanoyl thiosemicarbazide