1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

Base Information

Chemical Name:1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one
CAS No.:1610875-93-8
Molecular Formula:C₁₈H₂₂N₄O₄
Molecular Weight:358.397
Hs Code.:

Synonyms:1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

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Chemical Property of 1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

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Technology Process of 1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

There total 11 articles about 1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4460-86-0,14374-62-0
asaraldehyde

: 139756-02-8
4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

: 1610875-93-8
1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

Guidance literature:: With dipotassium peroxodisulfate; In water; dimethyl sulfoxide; at 100 ℃; for 0.05h; Sealed tube; Microwave irradiation;
DOI:10.1016/j.ejmech.2014.04.051

Reference yield:

: 92945-27-2
ethyl 3-propyl-1H-pyrazole-5-carboxylate

: 1610875-93-8
1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 80 °C

2: sodium hydroxide / 2 h / 80 °C

3: nitric acid; sulfuric acid / 4 h / 60 °C

4: N,N-dimethyl-formamide; thionyl chloride / chloroform / 3 h / Reflux

5: ammonium hydroxide / 0 °C

6: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

7: triethylamine / dichloromethane / 12 h / 25 °C

8: sodium ethanolate / ethanol / 12 h / Reflux

With ammonium hydroxide; thionyl chloride; tin(II) chloride dihdyrate; sulfuric acid; nitric acid; sodium ethanolate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane; chloroform;
DOI:10.1016/j.ejmech.2014.12.013

Reference yield:

: 133261-07-1
1-Methyl-3-n-propylpyrazole-5-carboxylic acid ethyl ester

: 1610875-93-8
1-methyl-3-propyl-5-(2,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7-(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / 2 h / 80 °C

2: nitric acid; sulfuric acid / 4 h / 60 °C

3: N,N-dimethyl-formamide; thionyl chloride / chloroform / 3 h / Reflux

4: ammonium hydroxide / 0 °C

5: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

6: triethylamine / dichloromethane / 12 h / 25 °C

7: sodium ethanolate / ethanol / 12 h / Reflux

With ammonium hydroxide; thionyl chloride; tin(II) chloride dihdyrate; sulfuric acid; nitric acid; sodium ethanolate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane; chloroform;
DOI:10.1016/j.ejmech.2014.12.013