1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one

Base Information

• Chemical Name: 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one
• CAS No.: 1643872-88-1
• Molecular Formula: C₂₈H₂₅NOS
• Molecular Weight: 423.579

Synonyms:1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one

Chemical Property of 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one

Chemical Property:

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Technology Process of 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one

There total 5 articles about 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-Acetyl-2,5-dimethylthiophen (2530-10-1) + 4-(N-(4-methylphenyl)-N-phenylamino)benzaldehyde (89115-21-9) → 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one (1643872-88-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1016/j.dyepig.2014.02.018

Reference yield:

2-Methylthiophene (554-14-3) → 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one (1643872-88-1)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 20 °C

2: hydrazine hydrate

3: aluminum (III) chloride / dichloromethane

4: sodium hydroxide / ethanol; water / 20 °C

With aluminum (III) chloride; hydrazine hydrate; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; 2: |Wolff-Kishner-Huang Minlon Reduction / 3: |Friedel-Crafts Acylation / 4: |Aldol Condensation;

DOI:10.1016/j.dyepig.2014.02.018

Reference yield:

diphenyl(p-tolyl)amine (4316-53-4) → 1-(2,5-dimethylthiophen-3-yl)-3-(4-(N-phenyl-N-(4-methylphenyl)amino)phenyl)prop-2-en-1-one (1643872-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate

2: sodium hydroxide / ethanol; water / 20 °C

With sodium hydroxide; trichlorophosphate; In ethanol; water; 2: |Aldol Condensation;

DOI:10.1016/j.dyepig.2014.02.018

upstream raw materials:

3-Acetyl-2,5-dimethylthiophen

4-(N-(4-methylphenyl)-N-phenylamino)benzaldehyde

2-Methylthiophene

5-methylthiophene-2-carboxaldehyde

Downstream raw materials:

1,5-bis(2,5-dimethylthiophen-3-yl)-3-{4-[phenyl(4-methylphenyl)amino]phenyl}pentane-1,5-dione

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