7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1335116-79-4
Molecular Formula:C₂₁H₁₈F₃NO₅S
Molecular Weight:453.439
Hs Code.:

Synonyms:7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Suppliers and Price of 7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 10 articles about 7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1335116-43-2
methyl 3-methyl-6-[(1-methylethyl)sulfonyl]-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1335116-79-4
7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: With hydrogen bromide; acetic acid; for 120h; Reflux;

Reference yield:

: 19056-40-7
4-bromo-3-methoxyaniline

: 1335116-79-4
7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 50 °C

1.2: 1 h / 80 °C

2.1: sulfuric acid / 1 h / 50 - 80 °C

3.1: potassium hydroxide / ethanol; water / 16 h / Reflux

3.2: pH 3

4.1: caesium carbonate / dimethyl sulfoxide / 2 h / 20 °C

5.1: copper(l) iodide / dimethyl sulfoxide / 50 - 120 °C / Inert atmosphere

5.2: 1 h / 20 °C

6.1: hydrogen bromide; acetic acid / 120 h / Reflux

With hydrogenchloride; copper(l) iodide; sulfuric acid; hydrogen bromide; caesium carbonate; acetic acid; potassium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1335116-79-4
7-hydroxy-3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.33 h

2.2: 100 °C

2.3: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4.1: hydrogen bromide; acetic acid / 120 h / Reflux

With hydrogen bromide; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; dimethyl sulfoxide; mineral oil;