2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

Base Information

Chemical Name:2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione
CAS No.:1027493-35-1
Molecular Formula:C₃₁H₂₅ClFN₃O₃S
Molecular Weight:574.075
Hs Code.:

Synonyms:2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

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Chemical Property of 2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

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Technology Process of 2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

There total 3 articles about 2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1027493-34-0
2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-methylthiophen-2-yl]isoindoline-1,3-dione

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1027493-35-1
2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm3007504

Reference yield:

: 50508-66-2
(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone

: 1027493-35-1
2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 18 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With N-Bromosuccinimide; triethylamine; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/jm3007504

Reference yield:

: 4640-66-8
p-chlorobenzoylacetonitrile

: 1027493-35-1
2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur; triethylamine / ethanol / 2 h / Inert atmosphere; Reflux

2: acetic acid / 18 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With N-Bromosuccinimide; sulfur; triethylamine; In ethanol; dichloromethane; acetic acid; acetonitrile; 1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1021/jm3007504