{2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

Base Information

Chemical Name:{2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone
CAS No.:1027493-08-8
Molecular Formula:C₂₃H₂₃ClFN₃OS
Molecular Weight:443.973
Hs Code.:

Synonyms:{2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

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Chemical Property of {2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

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Technology Process of {2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

There total 5 articles about {2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1027493-35-1
2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione

: 1027493-08-8
{2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/jm3007504

Reference yield:

: 50508-66-2
(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone

: 1027493-08-8
{2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 18 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

4: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/jm3007504

Reference yield:

: 4640-66-8
p-chlorobenzoylacetonitrile

: 1027493-08-8
{2-Amino-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sulfur; triethylamine / ethanol / 2 h / Inert atmosphere; Reflux

2: acetic acid / 18 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere; Cooling with ice

5: hydrazine hydrate / ethanol / 1 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; sulfur; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; acetic acid; acetonitrile; 1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1021/jm3007504