6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile

Base Information

Chemical Name:6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile
CAS No.:450844-31-2
Molecular Formula:C₁₉H₁₄BrN₅O
Molecular Weight:408.257
Hs Code.:
DSSTox Substance ID:DTXSID601119888

Synonyms:SCHEMBL5091243;DTXSID601119888;450844-31-2;6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile

Suppliers and Price of 6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:407.03817
Heavy Atom Count:26
Complexity:561

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C=NC=C1C(C2=CC=C(C=C2)C#N)OCC3=C(N=C(C=C3)C#N)Br

Technology Process of 6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile

There total 5 articles about 6-Bromo-5-[[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl]-2-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371765-91-2
4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

: 588731-33-3
6-bromo-5-bromomethyl-pyridine-2-carbonitrile

: 450844-31-2
6-bromo-5-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)pyridine-2-carbonitrile

Guidance literature:: With silver(l) oxide; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(03)00195-1

Reference yield:

: 3430-17-9
2-bromo-3-picoline

: 450844-31-2
6-bromo-5-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / mCPBA / CH₂Cl₂ / 20 °C

2: 31 percent / dimethylcarbamyl chloride / 1,2-dichloro-ethane / Heating

3: NBS; AIBN / CCl₄ / Heating

4: Ag₂O / CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; N,N-Dimethylcarbamoyl chloride; In tetrachloromethane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00195-1

Reference yield:

: 19230-57-0
2-bromo-3-methylpyridine 1-oxide

: 450844-31-2
6-bromo-5-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / dimethylcarbamyl chloride / 1,2-dichloro-ethane / Heating

2: NBS; AIBN / CCl₄ / Heating

3: Ag₂O / CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver(l) oxide; N,N-Dimethylcarbamoyl chloride; In tetrachloromethane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00195-1