19230-57-0

Basic information

• Product Name: 2-BroMo-3-Methylpyridine N-o×ide
• Synonyms: 2-BroMo-3-Methylpyridine N-o×ide;2-BroMo-3-Methylpyridine 1-oxide
• CAS NO: 19230-57-0
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02194
• Mol File: 19230-57-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-BroMo-3-Methylpyridine N-o×ide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-3-Methylpyridine N-o×ide(19230-57-0)
• EPA Substance Registry System: 2-BroMo-3-Methylpyridine N-o×ide(19230-57-0)

Safety Data

• Hazardous Substances Data: 19230-57-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-methylpyridine N-oxide is a chemical compound with the molecular formula C6H6BrNO. It is a brominated derivative of 3-methylpyridine and is commonly used as a reagent in organic synthesis. 2-BroMo-3-Methylpyridine N-o×ide is a white to off-white solid and is known to be stable under normal conditions. It is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Additionally, 2-Bromo-3-methylpyridine N-oxide has been studied for its potential use as a reagent in various chemical reactions due to its unique structure and properties.

Upstream product

• 3430-17-9 2-bromo-3-picoline 

Downstream Products

• 450844-27-6 6-bromo-5-methylpyridine-2-carbonitrile 
• 887571-15-5 2,6-dibromo-3-methylpyridine 
• 60323-97-9 2-bromo-3-methyl-4-nitropyridine N-oxide 
• 79055-55-3 2-bromo-3-methyl-4-nitropyridine 

Relevant articles and documents

A Journey through Hemetsberger–Knittel, Leimgruber–Batcho and Bartoli Reactions: Access to Several Hydroxy 5- and 6-Azaindoles

The preparation of various 5- and 6-azaindoles, heterocyclic structures that are frequently part of molecules in clinical development, and their monohydroxy analogues were described. Different strategies, relying on the de novo pyrrole ring formation, were investigated and, thanks to Hemetsberger–Knittel, Bartoli and Leimgruber–Batcho approaches, 4- and 7-monohydroxy 5- and 6-azaindoles were obtained. The crucial introduction of the oxygen atom was carried out from halogen derivatives, using nucleophilic substitution reactions under basic conditions with or without a copper catalyst. Some preliminary oxidation reactions have shown that it was yet not possible to synthesize the azaquinone indole structure from monohydroxy azaindole, using molecular oxygen in the presence of salcomine as a catalyst.

Technological method for preparing 2- amino -6-5-methyl-substituted-pyridine (by machine translation)

The reaction solvent of 2 - the method is reacted in a reaction solvent under the action, of 2 - an, acid anhydride and an acid,binding, agent and an amination reagent under the action. of an acid anhydride and 2 - an acid-binding agent and, an amination reagent, 2 -4 - 93/7, 99.8%, 70%. (by machine translation)

PROCESS FOR PREPARATION OF LUMACAFTOR

The present invention relates to a process for the preparation of amorphous lumacaftor. The present invention relates to a process for the preparation of intermediate 6-amino-2- halo-3-methylpyridine compounds used in the preparation of lumacaftor. The present invention relates to lumacaftor hydrobromide, process for its preparation and conversion thereof to lumacaftor.