3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

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Chemical Name:3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile
CAS No.:1150542-36-1
Molecular Formula:C₂₅H₃₀FN₃OSi
Molecular Weight:435.617
Hs Code.:

Synonyms:3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

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Chemical Property of 3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

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Technology Process of 3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

There total 2 articles about 3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1150542-42-9
triethyl((4-fluorophenyl)ethynyl)silane

: 1150542-35-0
6-iodo-5-(tetrahydro-2H-pyran-2-ylamino)picolinonitrile

: 1150542-36-1
3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

Guidance literature:: With sodium carbonate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 110 ℃; for 30h; Inert atmosphere;

Reference yield:

: 55338-73-3
5-amino-2-cyanopyridine

: 1150542-36-1
3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; silver sulfate / ethanol / 11 h / 20 °C

2: magnesium bromide / tetrahydrofuran / 48 h / Reflux

3: sodium carbonate; lithium chloride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 30 h / 110 °C / Inert atmosphere

With iodine; sodium carbonate; silver sulfate; lithium chloride; magnesium bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1150542-36-1
3-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-2-(triethylsilyl)-1H-pyrrolo-[3,2-b]pyridine-5-carbonitrile

: 1150542-38-3
3-(4-fluorophenyl)-2-iodo-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile

Guidance literature:: With trifluorormethanesulfonic acid; [bis(pyridine)iodine]⁺ tetrafluoroborate; In 1,2-dichloro-ethane; at 83 ℃;
DOI:10.1016/j.bmcl.2009.02.069