di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

Base Information

Chemical Name:di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate
CAS No.:1408443-98-0
Molecular Formula:C₄₀H₅₉NO₁₂S
Molecular Weight:777.974
Hs Code.:

di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

Synonyms:di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

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Chemical Property of di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

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Technology Process of di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

There total 11 articles about di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1407507-20-3
Di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

: 37002-45-2
(4S,5S)-2,2-dimethyl-4,5-bis(p-toluenesulfonyloxymethyl)-1,3-dioxolan

: 1408443-98-0
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1408443-98-0
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane; pyridine / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With pyridine; hydrogen; sodium hydride; potassium carbonate; Dess-Martin periodane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1408443-98-0
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(4-{[(4S,5S)-2,2-dimethyl-5-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,3-dioxolan-4-yl]methoxy}benzyl)hexanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

1.2: 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C

With hydrogen; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;