3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone

Base Information

• Chemical Name: 3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone
• CAS No.: 76799-58-1
• Molecular Formula: C₂₃H₂₄O₁₀
• Molecular Weight: 460.438
• Mol file: 76799-58-1.mol

Synonyms:3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone

Chemical Property of 3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone

There total 2 articles about 3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone (520-33-2,41001-90-5,69097-99-0) + methyl 2-acetoxy-4-bromobutyrate (76799-57-0) → 3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone (76799-58-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 72h; Ambient temperature;

DOI:10.1021/jm00136a011

Reference yield:

methyl 2,4-dibromobutanoate (29547-04-4,70288-65-2) → 3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone (76799-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / dimethylformamide / 1.) RT, 18 h, 2.) 50 deg C, 1 h

2: 76 percent / K₂CO₃ / dimethylformamide / 72 h / Ambient temperature

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00136a011

Reference yield: 36.0%

3',5-dihydroxy-4'-methoxy-7-(3-acetoxy-3-carbomethoxypropoxy)flavanone (76799-58-1) → 2,3',6-trihydroxy-4-(3-carboxy-3-hydroxypropoxy)-4'-methoxydihydrochalcone

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; for 18h; under 2280 Torr; Ambient temperature;

DOI:10.1021/jm00136a011

upstream raw materials:

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

methyl 2-acetoxy-4-bromobutyrate

methyl 2,4-dibromobutanoate