Technology Process of (5E,7E,13Z)-(9S,10S)-2-Benzenesulfonyl-10-methoxy-5,9,13-trimethyl-15-(2-trimethylsilanyl-ethoxymethoxy)-cycloheptadeca-5,7,13-triene-1,4-dione
There total 9 articles about (5E,7E,13Z)-(9S,10S)-2-Benzenesulfonyl-10-methoxy-5,9,13-trimethyl-15-(2-trimethylsilanyl-ethoxymethoxy)-cycloheptadeca-5,7,13-triene-1,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
acetonitrile;
at 45 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 87 percent / 1.) butyllithium / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h
2: 85 percent / Dess-Martin periodinane / CH2Cl2 / 1 h
3: 72 percent / cesium carbonate / acetonitrile / 3 h / 45 °C
With
n-butyllithium; caesium carbonate; Dess-Martin periodane;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / diisopropylamine, tetrabutylammonium iodide / CH2Cl2 / 2 h / Heating
2: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h
3: 88 percent / molecular sieves 4 Angstroem, 1-methylmorpholine-1-oxide, tetrapropylammonium perruthenate / CH2Cl2 / 0.5 h
4: 87 percent / 1.) butyllithium / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h
5: 85 percent / Dess-Martin periodinane / CH2Cl2 / 1 h
6: 72 percent / cesium carbonate / acetonitrile / 3 h / 45 °C
With
n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; caesium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;
