(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

Base Information

Chemical Name:(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione
CAS No.:210774-83-7
Molecular Formula:C₃₃H₅₁ClO₇SSi
Molecular Weight:655.368
Hs Code.:

(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

Synonyms:(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

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Chemical Property of (3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

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Technology Process of (3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

There total 8 articles about (3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 210778-76-0
(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-diol

: 210774-83-7
(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1h;

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 210774-83-7
(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 1.) butyllithium / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h

2: 85 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

With n-butyllithium; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 210774-83-7
(3E,5E,11Z)-(7S,8S)-17-Benzenesulfonyl-1-chloro-8-methoxy-3,7,11-trimethyl-13-(2-trimethylsilanyl-ethoxymethoxy)-heptadeca-3,5,11-triene-2,16-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / diisopropylamine, tetrabutylammonium iodide / CH₂Cl₂ / 2 h / Heating

2: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h

3: 88 percent / molecular sieves 4 Angstroem, 1-methylmorpholine-1-oxide, tetrapropylammonium perruthenate / CH₂Cl₂ / 0.5 h

4: 87 percent / 1.) butyllithium / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h

5: 85 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

With n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; 4-methylmorpholine N-oxide; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;