2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester
CAS No.:863762-22-5
Molecular Formula:C₂₃H₂₅FN₂O₅
Molecular Weight:428.46
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

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Chemical Property of 2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

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Technology Process of 2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

There total 6 articles about 2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 863762-12-3
2,2-dimethylpropionic acid 7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

: 30459-70-2
2-methyl-4-nitrobenzoyl chloride

: 863762-22-5
2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2006.05.070

Reference yield: 97.0%

: 863762-22-5
2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:

Reference yield:

: 804498-71-3
7-fluoro-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

: 863762-22-5
2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 2 h / Heating

2: PCl₅ / CH₂Cl₂ / 2 h / 20 °C

3: acetic acid; Zn / 0.5 h / Heating

4: BH₃*THF / tetrahydrofuran / 0.5 h / Heating

5: 97 percent / triethylamine / CH₂Cl₂ / 1 h / 20 °C

With borane-THF; phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate; acetic acid; triethylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2006.05.070