2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester
CAS No.:863762-26-9
Molecular Formula:C₂₃H₂₇FN₂O₃
Molecular Weight:398.477
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Suppliers and Price of 2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

There total 6 articles about 2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 863762-22-5
2,2-dimethylpropionic acid 7-fluoro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

: 863762-26-9
2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In ethanol; for 2h; Heating;
DOI:10.1016/j.bmc.2006.05.070

Reference yield:

: 804498-71-3
7-fluoro-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

: 863762-26-9
2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 2 h / Heating

2: PCl₅ / CH₂Cl₂ / 2 h / 20 °C

3: acetic acid; Zn / 0.5 h / Heating

4: BH₃*THF / tetrahydrofuran / 0.5 h / Heating

5: 97 percent / triethylamine / CH₂Cl₂ / 1 h / 20 °C

6: 78 percent / hydrochloric acid; SnCl₂ / ethanol / 2 h / Heating

With hydrogenchloride; borane-THF; phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate; acetic acid; triethylamine; tin(ll) chloride; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2006.05.070

Reference yield:

: 863762-12-3
2,2-dimethylpropionic acid 7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

: 863762-26-9
2,2-dimethylpropionic acid 1-(4-amino-2-methylbenzoyl)-7-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 1 h / 20 °C

2: 78 percent / hydrochloric acid; SnCl₂ / ethanol / 2 h / Heating

With hydrogenchloride; triethylamine; tin(ll) chloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2006.05.070