2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole
CAS No.:1443237-88-4
Molecular Formula:C₂₁H₂₄N₆O₄Si
Molecular Weight:452.545
Hs Code.:

Synonyms:2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

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Chemical Property of 2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

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Technology Process of 2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

There total 6 articles about 2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443237-87-3
N'-acetyl-4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbohydrazide

: 1443237-88-4
2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

Guidance literature:: With 1H-imidazole; carbon tetrabromide; triphenylphosphine; In dichloromethane; at 15 - 25 ℃; for 1h;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1443237-88-4
2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C / Inert atmosphere

1.2: 14.5 h / -78 - 30 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 1.5 h / 115 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

3.2: 4 h / 15 - 25 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 12 h / 15 - 25 °C

5.1: 1H-imidazole; carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 15 - 25 °C

With pyridine; 1H-imidazole; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon tetrabromide; sodium hydride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1443237-43-1
ethyl 4-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

: 1443237-88-4
2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

1.2: 4 h / 15 - 25 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 12 h / 15 - 25 °C

3.1: 1H-imidazole; carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 15 - 25 °C

With pyridine; 1H-imidazole; carbon tetrabromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; dichloromethane;