3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

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Chemical Name:3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline
CAS No.:1443237-89-5
Molecular Formula:C₂₁H₂₆N₆O₂Si
Molecular Weight:422.562
Hs Code.:

Synonyms:3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

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Chemical Property of 3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

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Technology Process of 3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

There total 7 articles about 3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443237-88-4
2-methyl-5-(4-(3-nitrophenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazole

: 1443237-89-5
3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 15 - 25 ℃; for 12h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1443237-89-5
3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C / Inert atmosphere

1.2: 14.5 h / -78 - 30 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / N,N-dimethyl-formamide / 1.5 h / 115 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

3.2: 4 h / 15 - 25 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 12 h / 15 - 25 °C

5.1: 1H-imidazole; carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 15 - 25 °C

6.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 15 - 25 °C / 760.05 Torr / Inert atmosphere

With pyridine; 1H-imidazole; n-butyllithium; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1443237-43-1
ethyl 4-(3-nitrophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

: 1443237-89-5
3-(5-(5-methyl-1,3,4-oxadiazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H pyrrolo[2,3-d]pyrimidin-4-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere

1.2: 4 h / 15 - 25 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 12 h / 15 - 25 °C

3.1: 1H-imidazole; carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 15 - 25 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 15 - 25 °C / 760.05 Torr / Inert atmosphere

With pyridine; 1H-imidazole; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;