n-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide

Base Information

Chemical Name:n-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide
CAS No.:96744-75-1
Molecular Formula:C₂₂H₃₂N₂O₂
Molecular Weight:356.508
Hs Code.:
UNII:J5S4K6TKTG
DSSTox Substance ID:DTXSID3046326
Nikkaji Number:J257.581G
Wikipedia:U-69,593
Wikidata:Q7862883
Pharos Ligand ID:GUXAR8T73J89
Metabolomics Workbench ID:66388
ChEMBL ID:CHEMBL440765
Mol file:96744-75-1.mol

n-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide

Synonyms:N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide;U 69593;U-69593

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of n-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:120-123℃
Boiling Point:518.7°Cat760mmHg
PKA:9.15±0.20(Predicted)
Flash Point:267.5°C
PSA：32.78000
Density:1.13g/cm³
LogP:3.19150
Storage Temp.:2-8°C
Solubility.:H2O: 14 mg/mL
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:356.246378268
Heavy Atom Count:26
Complexity:485

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN(C1CCC2(CCCO2)CC1N3CCCC3)C(=O)CC4=CC=CC=C4
Isomeric SMILES:CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)CC4=CC=CC=C4
Uses U-69593 is a selective κ-opioid receptor agonist. A safe opioid analgesic.
Biological Functions U-69593 is a single enantiomer with very high selectivity for the kappa receptor in vitro (mu/kappa ratio = 484). It was radiolabelled by a catalytic exchange of tritium for the two aromatic chlorine substituents of the precursor. This ligand is commercially available and has been widely used as a radiolabel for the kappa receptor.in spinal cordslice preparations from the 9-16-day-old rat,U-69593 produced a na-loxone-reversible depression of spontaneous and electrically evoked activityin dorsal horn neurones.

Technology Process of n-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide

There total 1 articles about n-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%