{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

Base Information

Chemical Name:{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone
CAS No.:1402937-02-3
Molecular Formula:C₂₇H₂₈ClNO₃
Molecular Weight:449.977
Hs Code.:

Synonyms:{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

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Chemical Property of {3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

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Technology Process of {3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

There total 3 articles about {3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 608537-49-1
N-methoxy-N,1-dimethylcyclopropane-1-carboxamide

: 1402937-01-2
2-chloro-5-iodo-N,N-bis(4-methoxybenzyl)aniline

: 1402937-02-3
{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

Guidance literature:: 2-chloro-5-iodo-N,N-bis(4-methoxybenzyl)aniline; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 - -40 ℃; for 0.5h; Inert atmosphere;

N-methoxy-N,1-dimethylcyclopropane-1-carboxamide; In tetrahydrofuran; diethyl ether; at -40 - 20 ℃; Inert atmosphere;

Reference yield:

: 16604-98-1
2-chloro-5-iodoaniline

: 1402937-02-3
{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 0.5 h / -78 - -40 °C / Inert atmosphere

2.2: -40 - 20 °C / Inert atmosphere

With isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1402937-02-3
{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 0.5 h / -78 - -40 °C / Inert atmosphere

2.2: -40 - 20 °C / Inert atmosphere

With isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;