Cyclopropanecarboxamide, N-methoxy-N,1-dimethyl- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxamide, N-methoxy-N,1-dimethyl- (9CI)
• CAS No.: 608537-49-1
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Mol file: 608537-49-1.mol

Synonyms:Cyclopropanecarboxamide, N-methoxy-N,1-dimethyl- (9CI)

Chemical Property of Cyclopropanecarboxamide, N-methoxy-N,1-dimethyl- (9CI)

Chemical Property:

• PSA: 29.54000
• LogP: 0.80630

Purity/Quality:

97% ^*data from raw suppliers

N-methoxy-N,1-dimethylcyclopropanecarboxamide 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxamide, N-methoxy-N,1-dimethyl- (9CI)

There total 5 articles about Cyclopropanecarboxamide, N-methoxy-N,1-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Methyl-cyclopropanoic acid (6914-76-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N,1-dimethylcyclopropane-1-carboxamide (608537-49-1)

Guidance literature:

1-Methyl-cyclopropanoic acid; With oxalyl dichloride; In diethyl ether; at 0 - 20 ℃; for 11h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With pyridine; In diethyl ether; chloroform; at 0 - 20 ℃; for 23h; Inert atmosphere;

DOI:10.1002/chem.200901463

Reference yield: 52.0%

1-Methyl-cyclopropanoic acid (6914-76-7) + N,0-dimethylhydroxylamine (1117-97-1) → N-methoxy-N,1-dimethylcyclopropane-1-carboxamide (608537-49-1)

Guidance literature:

1-Methyl-cyclopropanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

N,0-dimethylhydroxylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

1-methylcyclopropanecarbonyl chloride (16480-05-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N,1-dimethylcyclopropane-1-carboxamide (608537-49-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

upstream raw materials:

1-Methyl-cyclopropanoic acid

N,O-dimethylhydroxylamine*hydrochloride

N,0-dimethylhydroxylamine

1-methylcyclopropanecarbonyl chloride

Downstream raw materials:

{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}(1-methylcyclopropyl)methanone