(R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Base Information

Chemical Name:(R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide
CAS No.:1344707-35-2
Molecular Formula:C₂HF₃O₂*C₂₅H₁₉F₃N₆O₄
Molecular Weight:638.483
Hs Code.:

Synonyms:(R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Chemical Property of (R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Technology Process of (R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

There total 10 articles about (R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.1%

: 1344708-41-3,1344708-42-4,1344708-43-5
(R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 56-92-8
histamine dichloride

: 76-05-1
trifluoroacetic acid

: 1344707-35-2
(R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: (R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid; histamine dichloride; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 1h;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344707-35-2
(R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3.1: Jones reagent / acetone / 20 °C

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

7.2: Waters XBridge C₁₈

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344707-35-2
(R/S)-N-(2-(1H-imidazol-4-yl)ethyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2.1: Jones reagent / acetone / 20 °C

3.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

6.2: Waters XBridge C₁₈

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;